Areas of Current Research Interest:

• Computational and Structural Biology:
  • Studies on Protein-ligand interactions, identifications enzyme inhibitors, Structure based drug design using Molecular Modelling and Docking,

Contributions to Teaching:

• More than 20 years of teaching experience in PG level.
• Subjects handled include Biophysics, Bioinformatics, Biostatistics and Instrumentation

Funded Projects

• Identification and Modeling of Targets of an Endocrine Disruptor: Bisphenol-A . DBT, Govt. of India . 2008 - 2011
• Development of antifungal agents against Aspergillus flavus with alpha amylase as the target. KSCSTE, Govt.of Kerala . 2010 – 2013
• Design of Acetylcholinesterase inhibitors using the method of molecular modeling and docking . ICMR, Govt of India 2015 – 2018
• Study of Ubiquitination dependent modulation of proteinTyrosine Phosphatase Non Receptor type” (Co-PI) . KSCSTE-YIPB 2016-2019
• Isolation, characterization, gene expression and cytotoxic studies of antimycobacterial compounds from natural sources Kannur University . 2018-2020

List of Journal Publications

1. K. G. Arun, C. S. Sharanya, J. Abhithaj, Dileep Francis and C. Sadasivan (2020) Drug repurposing against SARS-CoV-2 using E-pharmacophore based virtual screening, molecular docking and molecular dynamics with main protease as the target, Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080.07391102.2020.1779819
2. K. G. Arun, C. S. Sharanya, J. Abhithaj and C. Sadasivan (2020) Repurposing of Streptomyces antibiotics as adenosine deaminase inhibitors by pharmacophore modeling, docking, molecular dynamics, and in vitro studies, Journl of Receptors and Signal Transduction, https://doi.org/10.1080/10799893.2020.1715432
3. KV Dileep, S Ashok, C Remya, KY Dharmendra, Horacio Pérez-Sánchez, C Sadasivan (2020)  Indole fragments for the design of lead molecules against pancreatitis,  Journal of Biomolecular Structure and Dynamics, 38 (1), 263-267. https://doi.org/10.1080/07391102.2019.1567389  (IF 3.31)
4. Mohan Shankar G, Vijai V Alex, Amrutha Nisthul A, Smitha V Bava, Sankar Sundaram, Archana P Retnakumari, Sadasivan Chittalakkottu and Ruby John Anto (2019) Pre‐clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer. Cell Proliferation, https://doi.org/10.1111/cpr.12710  (IF 5.039)
5. Arun K G, Sharanya C S, Abhithaj J and Sadasivan C  (2019) Biochemical and computational insights of adenosine deaminase inhibition by Epigallocatechin gallate.   Computational Biology and Chemistry, 83:107111.  (IF 1.581)
6. Amrutha Nisthul A, P Retnakumari Archana, Shankar G Mohan, Ruby John Anto, C Sadasivan  (2019)  Pyridine derivatives as anticancer lead compounds with Fatty Acid Synthase as the target: An in silico‐guided in vitro study. Journal of Cellular Biochemistry, 120: 16643-16657.  (IF 3.448)
7. PN Sunilkumar, C Sadasivan, KS Devaky, M Haridas (2019)  Solid-phase synthesis and solution conformation of two overlapping fragments of SPFE peptide using 2D-NMR, Indian Journal of Chemistry B,  58B(06), 714-719. (IF 0.509)
8. Remya Chandran, Mantosh Kumar, Lakshmi Kesavan, Reena Sarah Jacob, Sowmya Gunasekaran, Sethu Lakshmi, C Sadasivan, RV Omkumar  (2019) Cellular calcium signaling in the aging brain, Journal of chemical neuroanatomy, 95: 95-114. (IF 2.357).
9. LM Divya, GK Prasanth, KG Arun, C Sadasivan (2018) Bisphenol-A carbonate dimer is a more preferred substrate for laccase mediated degradation than the Biphenol-A in its monomeric and dimeric forms, International Biodeterioration & Biodegradatio, 135: 19-23. (IF 3.824)
10. KV Dileep, C Remya, I Tintu, PK Mandal, P Karthe, M Haridas, C Sadasivan (2018) Crystal structure of phospholipase A2 in complex with 1‐naphthalene acetic acid, IUBMB life 70 (10), 995-1001. (IF 3.051)
11. Amrutha Nisthul A., Archana P. Retnakumari, Shabna A., Ruby John Anto & C. Sadasivan (2018).    In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines,  Journal of Receptors and Signal Transduction 38(4), 335-341. (IF 1.629)
12. KG Arun, CS Sharanya, C Sadasivan (2018) Computational and experimental validation of morin as adenosine deaminase inhibitor, Journal of Receptors and Signal Transduction 38 (3), 240-245. (IF 1.629)
13. D.S. Jemima Beulin, Deepthi Radhakrishnan, Sharanya C. S. Chittalakottu Sadasivan, Masaya Yamaguchi, Shigetada Kawabata, and Karthe Ponnuraj, Streptococcus pneumoniae surface protein PfbA is a versatile multidomain and multiligand-binding adhesin employing different binding mechanisms. The FEBS journal, 284, (2017), 3404–3421.
14. Eeda Koti Reddy, Chandran Remya, Kumar Mantosh, Ayyiliath M. Sajith, R.V. Omkumar, C. Sadasivan, Shaik Anwar, “Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation”,  European Journal of Medicinal Chemistry 139 (2017) 367- 377.
15. Arun, K G, Sharany, C S, Sandeep, P M and Sadasivan, C. Inhibitory activity of hibifolin on adenosine deaminase- experimental and molecular modeling study’, Computational Biology and Chemistry 64 (2016) 353–358.
16. Divya Lakshmanan and C. Sadasivan, (2016) ‘Trichoderma viride Laccase Plays a Crucial Role in Defense Mechanism against Antagonistic Organisms’, Frontiers in Microbiology, 7 : 741.
17. C. Remya, K. V. Dileep, E. J. Variayr and C. Sadasivan,  (2016)  ‘An in silico guided identification of nAChR agonists from Withania somnifera’, Frontiers in Life Science,  9(3): 201-213.
18. Eeda Koti Reddy, Remya C., Ayyiliath M. Sajith, Dileep K. V., Sadasivan C. and Shaik Anwar, ‘Functionalised dihydroazo pyrimidine derivatives from Morita–Baylis–Hillman acetates: synthesis and studies against acetylcholinesterase as its Inhibitors’,  RSC Advances, 2016, 6, 77431
19. Sukumaran Surya, Joseph Abhilash, Krishnan Geethanandan, Chittalakkottu Sadasivan, Madhathilkovilakathu Haridas, ‘A profile of protein-protein interaction: Crystal structure of   a lectin-lectin comple’, International Journal of Biological Macromolecules, 87 (2016) 529–536.
20. Sukumaran Surya, Krishnan Geethanandan, Chittalakkottu Sadasivan, Madhathilkovilakathu Haridas, ‘Gallic acid binding to Spatholobus parviflorus lectin provides insight to its quaternary structure forming’, International Journal of Biological Macromolecules 91 (2016) 696–702.
21. K V Dileep, C Remya, J Cerezo, A Fassihi, H Pérez-Sánchez, C Sadasivan. Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway. Mol Biosyst 2015 Jul;11(7):1973-9.

22. Muringayil J Tomy, Chelankara S Sharanya, Kalarickal V Dileep, Shankar Prasanth, Abudulhameed Sabu, Chittalakkottu Sadasivan, Madathilkovilakathu Haridas. Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study. Chem Biol Drug Des 2015 Jun 17;85(6):715-21.

23. S R Aravind, Manu M Joseph, Suraj K George, K V Dileep, Sheeja Varghese, Alphy Rose-James, Prabha Balaram, C Sadasivan, T T Sreelekha. TRAIL-based tumor sensitizing galactoxyloglucan, a novel entity for targeting apoptotic machinery. Int J Biochem Cell Biol 2015 Feb 23;59:153-66.

24. J Abhilash, K Geethanandan, S R Bharath, A Sabu, C Sadasivan, M Haridas. The crystal structure of a lectin from Butea monosperma: insight into its glycosylation and binding of ligands. Int J Biol Macromol 2015 Jan;72:1376-8385(6):715-21.

25. Divya L.M, Prasanth G.K. and Sadasivan C., Assessing the tolerance of immobilized laccase from a salt-tolerant strain of Trichoderma viride Pers NFCCI-2745 to heavy metal ions, detergents and copper chelating agents, Int. J. Environ. Sci. Technol. 2015, Volume 12(10), 3225-3234

26. Divya G Nair, Sunilkumar P N & Sadasivan C., Interactions of some commonly used drugs with human α-thrombin, Journal of Biomolecular Structure and Dynamics 2015, 33(5), 1008-1015

27. Dileep KV, Remya C, Tintu I, Haridas M & Sadasivan C, Binding of NDGA and morin with phospholipase A2: experimental and computational evidences, Molecular Simulation, 2015, 41(4), 281-286

28. C. Remya, K.V. Dileep, I. Tintu, E.J. Variyar and C. Sadasivan, Flavanone glycosides as acetylcholinesterase inhibitors: Computational and experimental evidence, Indian Journal of Pharmaceutical Sciences 2014, 76(6), 567-570

29. Tintu I, Abhilash J, Dileep KV, Augustine A, Haridas M, Sadasivan C., A lectin from Spatholobus parviflorus inhibits Aspergillus flavus α-amylase: enzyme kinetics and thermodynamic studies. Chem Biol Drug Des. 2014 Jul;84(1):116-22.

30. Sujith Varma K and Sadasivan C, A Long Acting Biodegradable Controlled Delivery of Chitosan Microspheres Loaded With Tetanus Toxoide as Model Antigen,  Biomedicine & Pharmacotherapy, 68(2), 2014 March, 225–230

31. Dileep KV, Remya C, Tintu I, Haridas M, Sadasivan C: Inhibitory activity of IAA and IBA against lipoxygenase: in silico and in vitro validation. Molecular Simulation, April, 2014, 40(5), 418-422

32. Dileep KV, Remya C, Tintu I, Sadasivan C: Interactions of selected indole derivatives with COX-2 and their in silico structure modifications towards the development of novel NSAIDs. Journal of Biomolecular Structure & Dynamics 2014, 32(11), 1855-1863. .

33. Divya LM, Prasanth GK, Sadasivan C: Potential of the salt-tolerant laccase-producing strain Trichoderma viride Pers. NFCCI-2745 from an estuary in the bioremediation of phenol-polluted environments. Journal of Basic Microbiology 2014, Jun;54(6):542-7.

34. Tomy MJ Dileep KV, Prasanth S, Preethidan DS, Sabu A, Sadasivan C, Haridas M, Cuminaldehyde as a lipoxygenase inhibitor: in vitro and in silico validation., Appl Biochem Biotechnol. 2014 Sep;174(1):388-97.

35. Dileep K V, Remya C, Tintu I and Sadasivan C, Designing of multi-target-directed ligands against the enzymes associated with neuroinflammation: an in silico approach, Frontiers in Life Science, 2013, 7(3-4), 174-185.

36. Dileep K V, Remya C, Tintu I and Sadasivan C, Inhibition, ADME and Structure based modification of IAA and IBA against acetylcholinesterase: An attempt towards new drug development for Alzheimer’s disease, Frontiers in Life Science, 2013, 7(3-4), 164-173.

37. Abhilash J, Dileep KV, Palanimuthu M, Geethanandan K, Sadasivan C, Haridas M: Metal ions in sugar binding, sugar specificity and structural stability of Spatholobus parviflorus seed lectin. Journal of molecular modeling 2013, 19(8):3271-3278.

38. Aparna V, Dileep KV, Sadasivan C, Haridas M: Computational and thermodynamic analyses of the phospholipase A2 inhibition by erucic acid and linoleic acid. Med Chem Res 2013, 22(3):1102-1106.

39. Bhaskaran S, Dileep KV, Deepa SS, Sadasivan C, Klausner M, Krishnegowda NK, Tekmal RR, VandeBerg JL, Nair HB: Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. Molecular cancer therapeutics 2013, 12(4):361-372.

40. Dileep KV, Kelly M, Hardin E, Sadasivan C, Nair HB: Approaches in the Chemoprevention of Breast Cancer. Journal of Cancer Science and Therapy 2013, 5: 282-288.

41. Dileep KV, Remya C, Tintu I, Haridas M, Sadasivan C: Interactions of selected indole derivatives with phospholipase A(2): in silico and in vitro analysis. Journal of molecular modeling 2013, 19(4):1811-1817.

42. Divya LM, Prasanth GK, Sadasivan C: Elimination of estrogenic activity of thermal paper using laccase from Trichoderma sp NFCCI-2745. Applied biochemistry and biotechnology 2013, 169(4):1126-1133.

43. Geethanandan K, Joseph A, sadasivan C, Haridas M: Carbohydrate Binding and Unfolding of Spatholobus parviflorus Lectin: Fluorescence and Circular Dichroism Spectroscopic Study. Applied biochemistry and biotechnology 2013, 171(1):80-92.

44. Remya C, Dileep KV, Tintu I, Variyar EJ, Sadasivan C: In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile. Journal of molecular modeling 2013, 19(3):1179-1194.

45. Divya M, Prasanth GK, Sadasivan C: Isolation of a Salt Tolerant Laccase Secreting Strain of Trichoderma Sp NFCCI-2745 and Optimization of Culture Conditions and Assessing its Effectiveness in Treating Saline Phenolic Effluents. Journal of Environmental Sciences (China) 2013, Dec. 25(12), 2410-6.

46. Preethidan DS, Arun G, Prathyusha SM, Prasanth S, Sabu A, Sadasivan C, Haridas M: Lipoxygenase inhibitory activity of some Sida species due to di(2-ethylhexyl) phthalate. Current Science 2013, July. 105(2), 232

47. Aparna V, Dileep KV, Mandal PK, Karthe P, Sadasivan C, Haridas M: Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment. Chemical biology & drug design 2012, 80(3):434-439.

48. Chandra DN, Abhilash J, Prasanth GK, Sabu A, Sadasivan C, Haridas M: Inverted binding due to a minor structural change in berberine enhances its phospholipase A2 inhibitory effect. International journal of biological macromolecules 2012, 50(3):578-585.

49. Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C: Binding to PLA2 may contribute to the anti-inflammatory activity of catechol. Chemical biology & drug design 2012, 79(1):143-147.

50. Dileep KV, Tintu I, Remya C, Haridas M, Sadasivan C: Studies of IAA and IBA as fungal α-amylase inhibitors using enzyme kinetics, molecular modeling and thermodynamics. Starch - Stärke 2012, 64(12):991-995.

51. Naveen CD, Prasanth GK, Sadasivan C, Haridas M: Evaluation of biotransformed berberine derivatives as anti inflammatory drugs: an in silico study. Interdisciplinary sciences, computational life sciences 2012, 4(4):268-272.

52. Prasanth GK, M DL, Sadasivan C: Bisphenol-A Can Inhibit the Enzymatic Activity of Superoxide Dismutase. Human and Ecological Risk Assessment: An International Journal 2012, 19(1):268-277.

53. Remya C, Dileep KV, Tintu I, Variyar EJ, Sadasivan C: An in silico approach for the identification of inhibitors against Acetylcholinesterase. Med Chem Res 2012, 21(10):2779-2787.

54. Remya C, Dileep KV, Tintu I, Variyar EJ, Sadasivan C: Design of potent inhibitors of acetylcholinesterase using morin as the starting compound. Frontiers in Life Science 2012, 6(3-4):107-117.

55. Tintu I, Dileep KV, Augustine A, Sadasivan C: An isoquinoline alkaloid, berberine, can inhibit fungal alpha amylase: enzyme kinetic and molecular modeling studies. Chemical biology & drug design 2012, 80(4):554-560

56. Tintu I, Dileep KV, Remya C, Augustine A, Sadasivan C: 6-Gingerol inhibits fungal alpha amylase: Enzyme kinetic and molecular modeling studies. Starch - Stärke 2012, 64(8):607-612.

57. Abhilash J, Geethanandan K, Bharath SR, Sadasivan C, Haridas M: Crystallization and preliminary X-ray diffraction analysis of a galactose-specific lectin from the seeds of Butea monosperma. Acta crystallographica Section F, Structural biology and crystallization communications 2011, 67(Pt 4):524-526.

58. Chandra DN, Prasanth GK, Singh N, Kumar S, Jithesh O, Sadasivan C, Sharma S, Singh TP, Haridas M: Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93A and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine. Biochimica et biophysica acta 2011, 1814(5):657-663.

59. Dileep KV, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C: Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione. Frontiers in Life Science 2011, 5(3-4):135-139

60. Dileep KV, Tintu I, Sadasivan C: Molecular docking studies of curcumin analogs with phospholipase A2. Interdisciplinary sciences, computational life sciences 2011, 3(3):189-197.

61. Dileep KV, Tintu I, Vinod NV, Saliha PP, Sadasivan C: Role of invariant water molecules in retaining the active site geometry of β-lactamase: a molecular dynamics simulation study. Molecular Simulation 2011, 37(15):1234-1238.

62. Geethanandan K, Abhilash J, Bharath SR, Sadasivan C, Haridas M: X-ray structure of a galactose-specific lectin from Spatholobous parviflorous. International journal of biological macromolecules 2011, 49(5):992-998.

63. Geethanandan K, Abhilash J, Bharath SR, Sadasivan C, Haridas M: Crystallization and preliminary X-ray studies of a galactose-specific lectin from the seeds of Spatholobus parviflorus. Acta crystallographica Section F, Structural biology and crystallization communications 2011, 67(Pt 6):700-702.

64. Vinod NV, Sadasivan C: Screening of medicinal plants for antibacterial principles against beta-lactam resistant strains. Indian journal of pharmacology 2011, 43(1):92.

65. Varma SK, Sadasivan C: Development of Cross-linked Chitosan Microspheres for Prolonged Delivery of Macromolecular Drugs. International Journal of Research in Pharmacy and Chemistry. 2011, (1): 189-192.

66. Prasanth GK, Divya LM, Sadasivan C: Bisphenol-A can bind to human glucocorticoid receptor as an agonist: an in silico study. Journal of applied toxicology: 2010, 30(8):769-774

67. Vinod NV, Haridas M, Sadasivan C: Isolation of 1,4-naphthalenedione, an antibacterial principle from the leaves of Holoptelea integrifolia and its activity against beta-lactam resistant Staphylococcus aureus. Indian journal of biochemistry & biophysics 2010, 47(1):53-55.

68. Vinod NV, Shijina R, Dileep KV, Sadasivan C: Inhibition of beta-lactamase by 1,4-naphthalenedione from the plant Holoptelea integrifolia. Applied biochemistry and biotechnology 2010, 160(6):1752-1759.

69. Prasanth GK, Divya LM, Sadasivan C: Effects of mono and di(n-butyl) phthalate on superoxide dismutase. Toxicology 2009, 262(1):38-42.

70. Sunilkumar PN, Nair DG, Sadasivan C, Haridas M: Disruption mechanism in the helix of SPF peptide by interchanging E5 and K10 residues: inference from molecular dynamics study. Journal of biomolecular structure & dynamics 2009, 26(4):491-496.

71. Sunilkumar PN, Sadasivan C, Devaky KS, Haridas M: Synthesis and Conformation of a hexapeptide fragment (3-8) of SPF peptide by NMR and restrained molecular dynamics. Indian Journal of Chemistry 2009, (48): 1294-1298.

72. Divya G Nair, Sunilkumar PN, Sadasivan C: Modeling of factor XIII activation peptide (28-41) V34L mutant bound to thrombin. Journal of biomolecular structure & dynamics 2008, 26(3):387-394.

73. Rijamol KU, Toji Thomas, Sadasivan C: Antibacterial action of leaves of aegle marmelos. STARS: Int. Journal (Sciences), 2008, 2 (1):134-138

74. Sunilkumar PN, Sadasivan C, Devaky KS, Haridas M: Conformation of a residue substituted fragment (349-364) of human lactoferrin protein I DMSO-d6 by 1H NMR and restrained molecular dynamics. Indian Journal of Biochemistry & Biophysics 2008, (45): 51-56.

75. Sunilkumar PN, Sadasivan C, Devaky KS, Haridas M: Conformation of an octapeptide fragment (2-9) of kaliocin-1 in DMSO-d6 by 1H NMR and restrained molecular dynamics. Indian journal of biochemistry & biophysics 2007, 44(1):44-49.

76. Toji Thomas, Muraleedhara Kurup G, Sadasivan C: Antibacterial activity of Dicranopteris linearis under in vitro conditions. STARS: Int. Journal (Sciences) 2007, 1 (2):191-195.

77. Sunil Kumar PN, Devaky KS, Sadasivan C, Haridas M: Conformational analysis of sea cucumber (Caudina arenicola) C globin 94-97 fragment, Pro-Glu-Leu-Leu. Protein and peptide letters 2002, 9(5):403-409.

78. Sadasivan C, Yee VC: Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex. The Journal of biological chemistry 2000, 275(47):36942-36948.

79. Sadasivan C, Nagendra HG, Vijayan M: Plasticity, hydration and accessibility in ribonuclease A. The structure of a new crystal form and its low-humidity variant. Acta crystallographica Section D, Biological crystallography 1998, 54(Pt 6 Pt 2):1343-1352.

80. Sadasivan C, Gautham N: Sequence-dependent microheterogeneity of Z-DNA: the crystal and molecular structures of d(CACGCG).d(CGCGTG) and d(CGCACG).d(CGTGCG). Journal of molecular biology 1995, 248(5):918-930.

81. Sadasivan C and Gautham N: Plasticity of Z-DNA as observed in the crystal structures of non-selfcomplementary hexanucleotides. Current Science 1995, 68:531-537.

82. Bobde V, Durani S, Pattabhi V, Sadasivan C: Crystal structures of a D-residue containing tetrapeptides. tert-Boc-D-valyl-alanyl-leucyl-alanyl-methoxide, butanol solvate. International journal of peptide and protein research 1995, 45(4):332-336.

83. Sadasivan C, Karthe P, Gautham N: Space-group degeneracy in the packing of a non-selfcomplementary Z-DNA hexamer. Acta crystallographica Section D, Biological crystallography 1994, 50(Pt 2):192-196.

84. Sadasivan C, Pattabhi V, Gautham N, Vasanth S: Molecular structure and activity of Vicolides isolated fromVicoa indica. Journal of Crystallographic and Spectroscopic Research 1993, 23(4):339-344.

85. Nethaji M, Rufes C, Sadasivan C, Pattabhi V, Sharma OP: Molecular structure of Lantadene-B&C, triterpenoids ofantana camara, red variety: Lantadene-B, 22β-angeloyloxy-3-oxoolean-12-en-28-oic acid; Lantadene-C, 22 β-(S)-2′-methyl butanoyloxy-3-oxoolean-12-en-28-oic acid. Journal of Crystallographic and Spectroscopic Research 1993, 23(6):469-472.

86. Karthe P, Sadasivan C, Gautham N: Packing interactions of crystallographically independent molecules in organic crystals. Acta Crystallographica Section B 1993, 49(6):1069-1071.